| Basic Medical Informatin |
| brand name |
| Aricept, Aricept Odt |
Exelon, Exelon Td, Rivastigmine Td |
| Treatment For |
| Mild To Moderate Dementia Caused By Alzheimer's Disease |
Mild To Moderate Dementia Caused By Alzheimer's Or Parkinson's Disease |
| Legal Status |
| Rx-only |
Rx-only |
| Pregnancy cat. |
| C (us) |
B (us) |
| Possible Side Effects |
| Nausea, Diarrhea, Vomiting, Muscle Cramps, Fatigue And Loss Of Appetite, Headache, Fatigue
|
Vomiting Or Diarrhea, Loss Of Appetite, Weight Loss; Dry Mouth, Unable To Urinate, Heavy Sweating, Or Hot And Dry Skin; Black Or Bloody Stools, Coughing Up Blood Or Vomit; Restless Muscle Movements In Your Eyes, Tongue, Jaw, Or Neck; Tremors (uncontrolled Shaking); Seizure (convulsions); Headache, Tired Feeling; Dizziness, Spinning Feeling; Anxiety, Depressed Mood; Mild Nausea Or Stomach Pain; Muscle Weakness; Sleep Problems (insomnia); Skin Redness |
| Precautions & Contraindications |
| Heart Disease, Stomach Problems, Liver Or Kidney Disease, Breathing Problems, Urinary Obstruction, Brain Tumor, Head Injury, Seizures, Copd, And Pregnancy And Breastfeeding. |
Liver Or Kidney Disease; Recent Weight Loss Or Lack Of Appetite; A Heart Rhythm Disorder Such As "sick Sinus Syndrome" (slow Heartbeats); An Enlarged Prostate Or Urination Problems; Epilepsy Or Other Seizure Disorder; Asthma Or Other Breathng Disorder; A History Of Stomach Ulcer; Tremors (dyskinesia) Or Uncontrolled Muscle Movements. |
| Excretion |
| 0,11-0,13 (l/h/kg) |
Renal, 97% |
| Storage Conditions |
| 15° To 30°c, In An Airtight Container |
Room Temperature And In An Airtight Container |
|
| Dosage, Usage and Forms |
| Forms |
| Tablet |
|
| Routes (of administration) |
| Oral |
Oral, Transdermal |
|
Dosage |
| 5 mg |
6 (6-12 mg (Exelon), 1.5 mg (Rivastigmine TD)) |
| Chemical Data |
| Bioavailability |
| 100 % |
96 % |
| Protein binding |
| 96 % |
40 % |
| Metabolism |
| Hepatic |
Hepatic, Via Pseudocholinesterase |
| Half Life (hours) |
| 70 h |
1.5 h |
| Formula |
| C24h29no3 |
C14h22n2o2 |
| Molecular mass (g/mol) |
| 379.492 G/mol |
250.337 G/mol |