| Basic Medical Informatin |
| brand name |
| Exelon, Exelon Td, Rivastigmine Td |
Cognex |
| Treatment For |
| Mild To Moderate Dementia Caused By Alzheimer's Or Parkinson's Disease |
Mild To Moderate Dementia Caused By Alzheimer's Disease |
| Legal Status |
| Rx-only |
Rx-only |
| Pregnancy cat. |
| B (us) |
C (us) |
| Possible Side Effects |
| Vomiting Or Diarrhea, Loss Of Appetite, Weight Loss; Dry Mouth, Unable To Urinate, Heavy Sweating, Or Hot And Dry Skin; Black Or Bloody Stools, Coughing Up Blood Or Vomit; Restless Muscle Movements In Your Eyes, Tongue, Jaw, Or Neck; Tremors (uncontrolled Shaking); Seizure (convulsions); Headache, Tired Feeling; Dizziness, Spinning Feeling; Anxiety, Depressed Mood; Mild Nausea Or Stomach Pain; Muscle Weakness; Sleep Problems (insomnia); Skin Redness |
Nausea, Vomiting, Diarrhea, Indigestion, Muscle Pain, Loss Of Appetite And Unsteadiness |
| Precautions & Contraindications |
| Liver Or Kidney Disease; Recent Weight Loss Or Lack Of Appetite; A Heart Rhythm Disorder Such As "sick Sinus Syndrome" (slow Heartbeats); An Enlarged Prostate Or Urination Problems; Epilepsy Or Other Seizure Disorder; Asthma Or Other Breathng Disorder; A History Of Stomach Ulcer; Tremors (dyskinesia) Or Uncontrolled Muscle Movements. |
Ulcers, Seizures, Problems With Urinary System, Asthma, Blood Vessel Problems, Heart, Kidney, Liver, Lung Or Stomach Disorders |
| Excretion |
| Renal, 97% |
Renal |
| Storage Conditions |
| Room Temperature And In An Airtight Container |
15-30°c |
|
| Dosage, Usage and Forms |
| Forms |
|
Tablet |
| Routes (of administration) |
| Oral, Transdermal |
Oral, Rectal |
|
Dosage |
| 6 (6-12 mg (Exelon), 1.5 mg (Rivastigmine TD)) |
10 mg |
| Chemical Data |
| Bioavailability |
| 96 % |
24-36% |
| Protein binding |
| 40 % |
55 % |
| Metabolism |
| Hepatic, Via Pseudocholinesterase |
Hepatic |
| Half Life (hours) |
| 1.5 h |
2.9-3.6 H |
| Formula |
| C14h22n2o2 |
C13h14n2 |
| Molecular mass (g/mol) |
| 250.337 G/mol |
198.264 G/mol |